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gp130
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Does not bind IL6. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition. Belongs to the type I cytokine receptor family. Type 2 subfamily. Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, cytokine |
| Chromosomal Location of human Ortholog: 5q11.2 |
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Cellular Component:
ciliary neurotrophic factor receptor complex; dendrite; external side of plasma membrane; extracellular region; interleukin-6 receptor complex; membrane raft; neuronal cell body; oncostatin-M receptor complex; plasma membrane; receptor complex
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Molecular Function:
ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding; coreceptor activity; cytokine binding; cytokine receptor activity; growth factor binding; identical protein binding; interleukin-11 binding; interleukin-11 receptor activity; interleukin-27 receptor activity; interleukin-6 binding; interleukin-6 receptor activity; interleukin-6 receptor binding; leukemia inhibitory factor receptor activity; oncostatin-M receptor activity; protein binding; protein tyrosine kinase activator activity; scaffold protein binding
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Biological Process:
ciliary neurotrophic factor-mediated signaling pathway; cytokine-mediated signaling pathway; glycogen metabolic process; interleukin-11-mediated signaling pathway; interleukin-27-mediated signaling pathway; interleukin-6-mediated signaling pathway; intestinal epithelial cell development; leukemia inhibitory factor signaling pathway; negative regulation of apoptotic process; negative regulation of neuron apoptotic process; oncostatin-M-mediated signaling pathway; positive regulation of acute inflammatory response; positive regulation of adaptive immune response; positive regulation of astrocyte differentiation; positive regulation of cardiac muscle hypertrophy; positive regulation of cell population proliferation; positive regulation of Notch signaling pathway; positive regulation of osteoblast differentiation; positive regulation of platelet aggregation; positive regulation of T cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of vascular endothelial growth factor production; response to cytokine
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Disease: Hyper-ige Recurrent Infection Syndrome 4, Autosomal Recessive; Hyper-ige Recurrent Infection Syndrome 4a, Autosomal Dominant; Immunodeficiency 94 With Autoinflammation And Dysmorphic Facies; Stuve-wiedemann Syndrome 2
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Reference #:
P40189
(UniProtKB)
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Alt. Names/Synonyms: CD130; CD130 antigen; CDw130; gp130; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130 transducer chain; gp130, oncostatin M receptor; GP130-RAPS; HIES4; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; IL6R-beta; IL6RB; IL6ST; IL6ST nirs variant 3; interleukin 6 signal transducer; interleukin 6 signal transducer (gp130, oncostatin M receptor); interleukin receptor beta chain; Interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; membrane glycoprotein gp130; oncostatin M receptor; Oncostatin-M receptor subunit alpha; sGP130
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Gene Symbols: IL6ST
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Molecular weight:
103,537 Da
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Basal Isoelectric point:
5.62
Predict pI for various phosphorylation states
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CST Pathways:
IL6 Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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