gp130 Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Does not bind IL6. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition. Belongs to the type I cytokine receptor family. Type 2 subfamily. Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 5q11.2
Cellular Component:  ciliary neurotrophic factor receptor complex; dendrite; extracellular region; interleukin-6 receptor complex; neuronal cell body; oncostatin-M receptor complex; plasma membrane
Molecular Function:  ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding; growth factor binding; identical protein binding; interleukin-11 binding; interleukin-11 receptor activity; interleukin-27 receptor activity; protein binding; protein homodimerization activity
Biological Process:  ciliary neurotrophic factor-mediated signaling pathway; cytokine-mediated signaling pathway; glycogen metabolic process; interleukin-11-mediated signaling pathway; interleukin-27-mediated signaling pathway; interleukin-35-mediated signaling pathway; interleukin-6-mediated signaling pathway; leukemia inhibitory factor signaling pathway; negative regulation of apoptotic process; oncostatin-M-mediated signaling pathway; positive regulation of acute inflammatory response; positive regulation of adaptive immune response; positive regulation of astrocyte differentiation; positive regulation of cardiac muscle hypertrophy; positive regulation of cell proliferation; positive regulation of osteoblast differentiation; positive regulation of T cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of vascular endothelial growth factor production; regulation of Notch signaling pathway; response to cytokine; viral process
Disease: Hyper-ige Recurrent Infection Syndrome 4, Autosomal Recessive
Reference #:  P40189 (UniProtKB)
Alt. Names/Synonyms: CD130; CD130 antigen; CDw130; gp130; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130 transducer chain; GP130-RAPS; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; IL6R-beta; IL6RB; IL6ST; IL6ST nirs variant 3; interleukin 6 signal transducer (gp130, oncostatin M receptor); interleukin receptor beta chain; Interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; membrane glycoprotein gp130; oncostatin M receptor; Oncostatin-M receptor subunit alpha
Gene Symbols: IL6ST
Molecular weight: 103,537 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
CST Pathways:  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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