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SIPA1
GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression. Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, Ras |
| Chromosomal Location of mouse Ortholog: 19 A|19 4.34 cM |
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Cellular Component:
cytoplasm; membrane; nucleus; protein-containing complex; transport vesicle
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Molecular Function:
GTPase activator activity; protein C-terminus binding
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Biological Process:
cellular response to water deprivation; regulation of cell cycle; regulation of small GTPase mediated signal transduction
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Reference #:
P46062
(UniProtKB)
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Alt. Names/Synonyms: GTPase-activating protein Spa-1; KIAA4074; signal-induced proliferation associated gene 1; Signal-induced proliferation-associated protein 1; Sipa-1; Sipa1; Spa-1; Spa1
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Gene Symbols: Sipa1
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Molecular weight:
112,066 Da
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Basal Isoelectric point:
5.94
Predict pI for various phosphorylation states
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