SIPA1 GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression. Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras
Chromosomal Location of mouse Ortholog: 19 A|19 4.34 cM
Cellular Component:  cytoplasm; Golgi apparatus; membrane; nucleus; plasma membrane; protein-containing complex
Molecular Function:  GTPase activator activity
Biological Process:  activation of GTPase activity; cellular response to water deprivation; epithelial cell morphogenesis; establishment of epithelial cell polarity; regulation of cell cycle; regulation of small GTPase mediated signal transduction
Reference #:  P46062 (UniProtKB)
Alt. Names/Synonyms: GTPase-activating protein Spa-1; KIAA4074; signal-induced proliferation associated gene 1; Signal-induced proliferation-associated protein 1; Sipa-1; Sipa1; Spa-1; Spa1
Gene Symbols: Sipa1
Molecular weight: 112,066 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene