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SGOL2
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. Belongs to the shugoshin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of mouse Ortholog: 1 C1.3|1 28.86 cM |
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Cellular Component:
chromosome; chromosome, centromeric region; condensed chromosome, centromeric region; kinetochore; mitotic cohesin complex; nuclear body; nucleoplasm; nucleus
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Molecular Function:
protein binding
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Biological Process:
cell cycle; cell division; chromosome segregation; female meiotic nuclear division; maintenance of meiotic sister chromatid cohesion, centromeric; male meiotic nuclear division; meiotic cell cycle; meiotic sister chromatid cohesion; meiotic sister chromatid cohesion involved in meiosis I; meiotic sister chromatid cohesion, centromeric; positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric; protein localization
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Reference #:
Q7TSY8
(UniProtKB)
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Alt. Names/Synonyms: 1110007N04Rik; 4932411A20Rik; 5730576N04Rik; AU018846; AV008062; D1Ertd8; D1Ertd8e; OTTMUSP00000024449; Sgo2; Sgo2a; Sgol2; Sgol2a; Shugoshin 2; shugoshin 2A; Shugoshin-2; Shugoshin-like 2; shugoshin-like 2 (S. pombe); shugoshin-like 2a; Tripin
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Gene Symbols: Sgo2a
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Molecular weight:
130,277 Da
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Basal Isoelectric point:
8.97
Predict pI for various phosphorylation states
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