SFRS7 Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. Belongs to the splicing factor SR family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 17|17 E3
Cellular Component:  cytoplasm; nuclear speck; nucleoplasm; nucleus
Molecular Function:  metal ion binding; nucleic acid binding; protein binding; protein domain specific binding; RNA binding; zinc ion binding
Biological Process:  cellular response to leukemia inhibitory factor; mRNA cis splicing, via spliceosome; mRNA processing; mRNA transport; negative regulation of mRNA splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome; RNA splicing
Reference #:  Q8BL97 (UniProtKB)
Alt. Names/Synonyms: 35kDa; 9430065L19Rik; 9G8; MGC38287; NX-96; Serine/arginine-rich splicing factor 7; Sfrs7; Splicing factor, arginine/serine-rich 7; Srsf7
Gene Symbols: Srsf7
Molecular weight: 30,818 Da
Basal Isoelectric point: 11.89  Predict pI for various phosphorylation states
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SFRS7

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene