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TRA2B
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. Belongs to the splicing factor SR family. Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing; RNA-binding; Spliceosome |
| Chromosomal Location of mouse Ortholog: 16 B1|16 13.18 cM |
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Cellular Component:
nuclear inner membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein-containing complex; spliceosomal complex
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Molecular Function:
identical protein binding; mRNA binding; nucleic acid binding; pre-mRNA binding; protein binding; protein domain specific binding; RNA binding
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Biological Process:
cellular response to glucose stimulus; cerebral cortex regionalization; embryonic brain development; mRNA processing; mRNA splicing, via spliceosome; positive regulation of mRNA splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome; regulation of RNA splicing; RNA splicing
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Reference #:
P62996
(UniProtKB)
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Alt. Names/Synonyms: 5730405G21Rik; D16Ertd266e; MGC102169; Sfr; Sfrs10; SIG-41; Sil; Silg41; Silica-induced gene 41 protein; Splicing factor, arginine/serine-rich 10; splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila); TRA-2 beta; TRA2-beta; Tra2b; TRA2beta; transformer 2 beta; transformer 2 beta homolog; transformer 2 beta homolog (Drosophila); Transformer-2 protein homolog B; Transformer-2 protein homolog beta
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Gene Symbols: Tra2b
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Molecular weight:
33,666 Da
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Basal Isoelectric point:
11.25
Predict pI for various phosphorylation states
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