SEC24B Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes. Belongs to the SEC23/SEC24 family. SEC24 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of mouse Ortholog: 3|3 G3
Cellular Component:  COPII vesicle coat; COPII-coated ER to Golgi transport vesicle; cytosol; endoplasmic reticulum exit site
Molecular Function:  protein binding; SNARE binding; zinc ion binding
Biological Process:  aorta morphogenesis; auditory receptor cell morphogenesis; auditory receptor cell stereocilium organization; circulatory system development; cochlear nucleus development; COPII-coated vesicle cargo loading; coronary artery morphogenesis; endoplasmic reticulum to Golgi vesicle-mediated transport; lung lobe morphogenesis; lung morphogenesis; neural tube closure; outflow tract morphogenesis; pulmonary artery morphogenesis; regulation of cargo loading into COPII-coated vesicle; regulation of establishment of planar polarity involved in neural tube closure
Reference #:  Q80ZX0 (UniProtKB)
Alt. Names/Synonyms: AI605202; protein transport protein Sec24B; SEC2; SEC24; Sec24 related gene family, member B; Sec24 related gene family, member B (S. cerevisiae); Sec24-related gene family, member B (S. cerevisiae); Sec24b
Gene Symbols: Sec24b
Molecular weight: 135,551 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene