DAB1 Adapter molecule functioning in neural development. May regulate SIAH1 activity. Mainly expressed in brain. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 1p32.2-p32.1
Cellular Component:  apical part of cell; brush border; cytosol; intracellular membrane-bounded organelle; membrane; neuron projection; neuronal cell body; perinuclear region of cytoplasm; postsynaptic density
Molecular Function:  phosphatidylinositol 3-kinase binding; protein binding
Biological Process:  adult walking behavior; axon guidance; cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration; cerebellum structural organization; dendrite development; Golgi localization; hippocampus development; lateral motor column neuron migration; midgut development; negative regulation of astrocyte differentiation; negative regulation of axonogenesis; negative regulation of cell adhesion; negative regulation of JAK-STAT cascade; positive regulation of neuron differentiation; positive regulation of protein kinase activity; radial glia guided migration of Purkinje cell; response to drug; small GTPase mediated signal transduction; ventral spinal cord development
Disease: Spinocerebellar Ataxia 37
Reference #:  O75553 (UniProtKB)
Alt. Names/Synonyms: DAB adaptor protein 1; Dab reelin signal transducer 1; Dab, reelin signal transducer, homolog 1; DAB1; DAB1, reelin adaptor protein; Disabled homolog 1; disabled homolog 1 (Drosophila); SCA37
Gene Symbols: DAB1
Molecular weight: 63,775 Da
Basal Isoelectric point: 4.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene