RPL13A Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA. Belongs to the universal ribosomal protein uL13 family. Note: This description may include information from UniProtKB.
Protein type: Ribosomal; Translation
Chromosomal Location of Human Ortholog: 7 B3|7 29.14 cM
Cellular Component:  cytosolic large ribosomal subunit; GAIT complex; large ribosomal subunit; ribonucleoprotein complex; ribosome
Molecular Function:  mRNA binding; structural constituent of ribosome
Biological Process:  cellular response to interferon-gamma; homeostatic process; lung morphogenesis; macrophage chemotaxis; negative regulation of formation of translation preinitiation complex; negative regulation of translation; regulation of translation; response to lipopolysaccharide; translation
Reference #:  P19253 (UniProtKB)
Alt. Names/Synonyms: 1810026N22Rik; 60S ribosomal protein L13a; MGC107571; OTTMUSP00000017768; P198; ribosomal protein L13A; RL13A; Rpl13a; tissue specific transplantation antigen P198-7; Transplantation antigen P198; Tstap198-7; tum-antigen; Tum-P198 antigen; tum-transplantation antigen P198
Gene Symbols: Rpl13a
Molecular weight: 23,464 Da
Basal Isoelectric point: 11.02  Predict pI for various phosphorylation states
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RPL13A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene