RHOG Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry. Belongs to the small GTPase superfamily. Rho family. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 7|7 E2
Cellular Component:  cell projection; cytoplasmic vesicle; cytoskeleton; membrane; plasma membrane
Molecular Function:  GTP binding; GTPase activity; nucleotide binding; protein binding; protein kinase binding
Biological Process:  actin cytoskeleton organization; actin filament organization; activation of GTPase activity; cell chemotaxis; cortical cytoskeleton organization; establishment or maintenance of cell polarity; positive regulation of DNA-templated transcription; positive regulation of protein localization to plasma membrane; Rac protein signal transduction; regulation of actin cytoskeleton organization; regulation of cell shape; regulation of ruffle assembly; Rho protein signal transduction; small GTPase mediated signal transduction
Reference #:  P84096 (UniProtKB)
Alt. Names/Synonyms: 2810426G09Rik; aplysia ras-related homolog G (RhoG); Arhg; OTTMUSP00000025699; OTTMUSP00000025700; ras homolog family member G; ras homolog G (RhoG); ras homolog gene family, member G; Rho-related GTP-binding protein RhoG; Rhog; Sid 10750; Sid107; Sid10750
Gene Symbols: Rhog
Molecular weight: 21,309 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein