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RHOG
Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry. Belongs to the small GTPase superfamily. Rho family. Note: This description may include information from UniProtKB.
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| Protein type: G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 7|7 E2 |
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Cellular Component:
cell projection; cytoplasmic vesicle; cytoskeleton; membrane; plasma membrane
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Molecular Function:
GTP binding; GTPase activity; nucleotide binding; protein binding; protein kinase binding
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Biological Process:
actin cytoskeleton organization; actin filament organization; activation of GTPase activity; cell chemotaxis; cortical cytoskeleton organization; establishment or maintenance of cell polarity; positive regulation of DNA-templated transcription; positive regulation of protein localization to plasma membrane; Rac protein signal transduction; regulation of actin cytoskeleton organization; regulation of cell shape; regulation of ruffle assembly; Rho protein signal transduction; small GTPase mediated signal transduction
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Reference #:
P84096
(UniProtKB)
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Alt. Names/Synonyms: 2810426G09Rik; aplysia ras-related homolog G (RhoG); Arhg; OTTMUSP00000025699; OTTMUSP00000025700; ras homolog family member G; ras homolog G (RhoG); ras homolog gene family, member G; Rho-related GTP-binding protein RhoG; Rhog; Sid 10750; Sid107; Sid10750
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Gene Symbols: Rhog
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Molecular weight:
21,309 Da
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Basal Isoelectric point:
8.41
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Microtubule Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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