RGS14 Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, RGS
Chromosomal Location of mouse Ortholog: 13 B1|13 29.8 cM
Cellular Component:  cell projection; centrosome; cytoplasm; cytoskeleton; dendrite; dendritic spine; glutamatergic synapse; membrane; microtubule; nuclear body; nucleus; plasma membrane; postsynaptic density; spindle; spindle pole; synapse
Molecular Function:  G-protein alpha-subunit binding; GDP-dissociation inhibitor activity; GTPase activating protein binding; GTPase activator activity; GTPase regulator activity; microtubule binding; protein binding; protein kinase binding; signaling receptor complex adaptor activity
Biological Process:  cell cycle; cell division; chromosome segregation; G protein-coupled receptor signaling pathway; learning; long-term memory; long-term synaptic potentiation; mitotic cell cycle; modulation of chemical synaptic transmission; multicellular organism development; negative regulation of ERK1 and ERK2 cascade; negative regulation of G protein-coupled receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of signal transduction; negative regulation of synaptic plasticity; nucleocytoplasmic transport; platelet-derived growth factor receptor signaling pathway; positive regulation of GTPase activity; positive regulation of neurogenesis; regulation of DNA-templated transcription in response to stress; regulation of G protein-coupled receptor signaling pathway; response to oxidative stress; signal transduction; spindle organization; visual learning; zygote asymmetric cell division
Reference #:  P97492 (UniProtKB)
Alt. Names/Synonyms: rap1/rap2 interacting protein; RAP1/RAP2-interacting protein; Regulator of G-protein signaling 14; RGS14; RPIP1
Gene Symbols: Rgs14
Molecular weight: 59,847 Da
Basal Isoelectric point: 7.14  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein