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RFX1
Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. Belongs to the RFX family. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of Human Ortholog: 8 C2|8 40.28 cM |
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Cellular Component:
intracellular membrane-bounded organelle; nucleoplasm; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription factor activity; RNA polymerase II proximal promoter sequence-specific DNA binding
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Biological Process:
regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
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Reference #:
P48377
(UniProtKB)
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Alt. Names/Synonyms: AI047719; AI385641; MHC class II regulatory factor RFX1; Regulatory factor X 1; regulatory factor X, 1 (influences HLA class II expression); Rfx1; Transcription factor RFX1; vregulatory factor X, 1 (influences HLA class II expression)
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Gene Symbols: Rfx1
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Molecular weight:
103,707 Da
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Basal Isoelectric point:
5.93
Predict pI for various phosphorylation states
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