RERE Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. Widely expressed. Expressed in tumor cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 4 E2|4 81.34 cM
Cellular Component:  histone deacetylase complex; nucleus
Molecular Function:  chromatin binding; DNA binding; metal ion binding; protein binding; RNA polymerase II transcription factor binding; sequence-specific DNA binding; transcription coactivator activity; transcription corepressor activity; zinc ion binding
Biological Process:  branching morphogenesis of a nerve; cerebellar granule cell precursor proliferation; cerebellar Purkinje cell layer maturation; cerebellum development; chromatin remodeling; dendrite morphogenesis; multicellular organism development; radial glia guided migration of Purkinje cell; regulation of transcription, DNA-templated
Reference #:  Q80TZ9 (UniProtKB)
Alt. Names/Synonyms: 1110033A15Rik; AI414665; ARG; arginine glutamic acid dipeptide (RE) repeats; Arginine-glutamic acid dipeptide repeats protein; ARP; ATN1L; Atr2; Atrophin-2; AW742570; DNB1; Kiaa0458; mKIAA0458; OTTMUSP00000011146; Rere
Gene Symbols: Rere
Molecular weight: 171,755 Da
Basal Isoelectric point: 7.44  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA