SHP-2 Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. Widely expressed, with highest levels in heart, brain, and skeletal muscle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 12q24.13
Cellular Component:  cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  cell adhesion molecule binding; D1 dopamine receptor binding; insulin receptor binding; insulin receptor substrate binding; non-membrane spanning protein tyrosine phosphatase activity; peptide hormone receptor binding; phospholipase binding; phosphoprotein phosphatase activity; phosphotyrosine residue binding; protein binding; protein domain specific binding; protein kinase binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; SH3/SH2 adaptor activity
Biological Process:  abortive mitotic cell cycle; activation of MAPK activity; atrioventricular canal development; axon guidance; Bergmann glial cell differentiation; brain development; cellular response to cytokine stimulus; cellular response to epidermal growth factor stimulus; cellular response to mechanical stimulus; cerebellar cortex formation; cytokine-mediated signaling pathway; DNA damage checkpoint; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; ERBB signaling pathway; face morphogenesis; fibroblast growth factor receptor signaling pathway; genitalia development; glucose homeostasis; heart development; homeostasis of number of cells within a tissue; hormone metabolic process; hormone-mediated signaling pathway; inner ear development; integrin-mediated signaling pathway; interleukin-6-mediated signaling pathway; intestinal epithelial cell migration; leukocyte migration; megakaryocyte development; microvillus organization; multicellular organism growth; multicellular organismal reproductive process; negative regulation of cell adhesion mediated by integrin; negative regulation of cortisol secretion; negative regulation of growth hormone secretion; negative regulation of insulin secretion; neurotrophin TRK receptor signaling pathway; organ growth; peptidyl-tyrosine dephosphorylation; platelet activation; platelet formation; platelet-derived growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of glucose import; positive regulation of hormone secretion; positive regulation of insulin receptor signaling pathway; positive regulation of interferon-beta production; positive regulation of interleukin-6 production; positive regulation of mitotic cell cycle; positive regulation of protein kinase B signaling; positive regulation of tumor necrosis factor production; regulation of cell adhesion mediated by integrin; regulation of protein complex assembly; regulation of protein export from nucleus; regulation of type I interferon-mediated signaling pathway; T cell costimulation; triglyceride metabolic process
Disease: Juvenile Myelomonocytic Leukemia; Leopard Syndrome 1; Metachondromatosis; Noonan Syndrome 1
Reference #:  Q06124 (UniProtKB)
Alt. Names/Synonyms: BPTP3; CFC; JMML; METCDS; MGC14433; NS1; protein tyrosine phosphatase non-receptor type 11; protein tyrosine phosphatase, non-receptor type 11; protein tyrosine phosphatase-2; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; PTN11; PTP-1D; PTP-2C; PTP2C; PTPN11; SH-PTP2; SH-PTP3; SHP-2; Shp2; SHPTP2; Tyrosine-protein phosphatase non-receptor type 11
Gene Symbols: PTPN11
Molecular weight: 68,011 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  IL6 Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SHP-2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene