RBM4 RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. Expressed in the cerebellum. Expressed in neurons and glial cells, including layers II neurons in the frontal cortex and CA1 pyramidal neurons in the hippocampus. Expressed in heart, liver, pancreas, skeletal muscle, placenta, primary fibroblasts and peripheral blood monocytes (at protein level). Ubiquitously expressed. Highly expressed in heart, placenta and skeletal muscle. Weakly expressed in pancreas, kidney, liver, lung and brain. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 19|19 A
Cellular Component:  cytoplasm; cytoplasmic stress granule; cytosol; nuclear speck; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm
Molecular Function:  cyclin binding; metal ion binding; miRNA binding; mRNA 3'-UTR binding; mRNA binding; nucleic acid binding; pre-mRNA binding; pre-mRNA intronic binding; pre-mRNA intronic pyrimidine-rich binding; RNA binding; zinc ion binding
Biological Process:  cap-independent translational initiation; cell differentiation; circadian regulation of gene expression; circadian regulation of translation; enteroendocrine cell differentiation; entrainment of circadian clock by photoperiod; gene silencing by RNA; glucose homeostasis; insulin secretion involved in cellular response to glucose stimulus; IRES-dependent translational initiation of linear mRNA; miRNA mediated inhibition of translation; mRNA cis splicing, via spliceosome; mRNA processing; negative regulation of translation; negative regulation of translation in response to stress; negative regulation of translational initiation; pancreas development; positive regulation of muscle cell differentiation; positive regulation of translation; regulation of alternative mRNA splicing, via spliceosome; regulation of gene expression; regulation of insulin receptor signaling pathway; regulation of nucleocytoplasmic transport; response to arsenic-containing substance; RNA splicing
Reference #:  Q8C7Q4 (UniProtKB)
Alt. Names/Synonyms: 4921506I22Rik; lark; Lark homolog; Lark1; mLark; Rbm; Rbm4; Rbm4a; RNA binding motif protein 4; RNA-binding motif protein 4; RNA-binding motif protein 4a; RNA-binding protein 4
Gene Symbols: Rbm4
Molecular weight: 40,046 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene