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RBM15
RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation. Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation. Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen. Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL. May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation. Belongs to the RRM Spen family. 4 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Oncoprotein; RNA-binding; Spliceosome |
| Chromosomal Location of mouse Ortholog: 3|3 F2.3 |
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Cellular Component:
membrane; nuclear speck; nucleoplasm; nucleus; RNA N6-methyladenosine methyltransferase complex
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Molecular Function:
mRNA binding; nucleic acid binding; protein binding; RNA binding
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Biological Process:
branching involved in blood vessel morphogenesis; dosage compensation by inactivation of X chromosome; negative regulation of myeloid cell differentiation; negative regulation of transcription by RNA polymerase II; placenta blood vessel development; positive regulation of transcription of Notch receptor target; regulation of alternative mRNA splicing, via spliceosome; regulation of megakaryocyte differentiation; RNA methylation; spleen development; thrombopoietin-mediated signaling pathway; ventricular septum morphogenesis
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Reference #:
Q0VBL3
(UniProtKB)
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Alt. Names/Synonyms: C230088J01Rik; KIAA1438; Kiaa4257; mKIAA1438; mKIAA4257; One-twenty two protein 1; Ott1; putative RNA-binding protein 15; Rbm15; RNA binding motif protein 15; RNA-binding motif protein 15; RNA-binding protein 15
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Gene Symbols: Rbm15
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Molecular weight:
105,722 Da
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Basal Isoelectric point:
10.09
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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