RAPGEF6 Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Ras
Chromosomal Location of Human Ortholog: 11|11 B1.3
Cellular Component:  apical plasma membrane; centrosome; cytosol; endocytic vesicle; plasma membrane
Molecular Function:  GTP-dependent protein binding; guanyl-nucleotide exchange factor activity; phosphatidic acid binding; Ras GTPase binding
Biological Process:  microvillus assembly; positive regulation of GTPase activity; protein localization to plasma membrane
Reference #:  Q5NCJ1 (UniProtKB)
Alt. Names/Synonyms: A530068K01; AI844632; BB085664; C030018K18Rik; KIAA4052; mKIAA4052; OTTMUSP00000005847; PDZ domain containing guanine nucleotide exchange factor (GEF) 2; PDZ domain containing guanine nucleotide exchange factor(GEF)1; PDZ-GEF2; Pdzgef2; RA-GEF-2; Ragef2; Rap guanine nucleotide exchange factor (GEF) 6; rap guanine nucleotide exchange factor 2; Rapgef6
Gene Symbols: Rapgef6
Molecular weight: 180,240 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene