PSMD1 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Belongs to the proteasome subunit S1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 1|1 C5
Cellular Component:  nucleus; proteasome accessory complex; proteasome complex; proteasome regulatory particle, base subcomplex; proteasome storage granule
Molecular Function:  enzyme regulator activity; protein binding; ubiquitin protein ligase binding
Biological Process:  proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of protein catabolic process
Reference #:  Q3TXS7 (UniProtKB)
Alt. Names/Synonyms: 2410026J11Rik; 26S proteasome non-ATPase regulatory subunit 1; 26S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1; P112; proteasome (prosome, macropain) 26S subunit, non-ATPase, 1; Psmd1; S1
Gene Symbols: Psmd1
Molecular weight: 105,730 Da
Basal Isoelectric point: 5.25  Predict pI for various phosphorylation states
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PSMD1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene