RAD51 Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair. Belongs to the RecA family. RAD51 subfamily. Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Mitochondrial
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component:  chromatin; condensed chromosome; condensed nuclear chromosome; cytoplasm; cytosol; lateral element; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear chromatin; nuclear chromosome; nuclear chromosome, telomeric region; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; PML body; protein-containing complex; site of double-strand break
Molecular Function:  ATP binding; chromatin binding; DNA polymerase binding; double-stranded DNA binding; enzyme binding; identical protein binding; protein binding; protein C-terminus binding; single-stranded DNA binding; single-stranded DNA-dependent ATPase activity
Biological Process:  cellular response to camptothecin; cellular response to DNA damage stimulus; cellular response to ionizing radiation; DNA recombinase assembly; DNA recombination; DNA repair; DNA unwinding involved in DNA replication; double-strand break repair via homologous recombination; interstrand cross-link repair; meiotic cell cycle; mitotic recombination-dependent replication fork processing; negative regulation of G0 to G1 transition; positive regulation of DNA ligation; protein homooligomerization; regulation of double-strand break repair via homologous recombination; replication fork processing; telomere maintenance via recombination; telomere maintenance via telomere lengthening
Disease: Breast Cancer; Fanconi Anemia, Complementation Group R; Mirror Movements 2
Reference #:  Q06609 (UniProtKB)
Alt. Names/Synonyms: BRCA1/BRCA2-containing complex, subunit 5; BRCC5; DNA repair protein RAD51 homolog 1; FANCR; hRAD51; HsRAD51; HsT16930; MRMV2; RAD51; RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae); RAD51 homolog A; RAD51 homolog protein; RAD51 recombinase; RAD51A; RECA; RecA, E. coli, homolog of; RecA-like protein; recombination protein A
Gene Symbols: RAD51
Molecular weight: 36,966 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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