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PIK4CB
a member of the PI3/PI4 kinase family. Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate. Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-biphosphate (PIP2) on the Golgi complex. May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Three splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 3|3 F2.1 |
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Cellular Component:
cytoplasm; cytosol; endoplasmic reticulum; Golgi apparatus; Golgi membrane; membrane; mitochondrial outer membrane; mitochondrion; plasma membrane
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Molecular Function:
1-phosphatidylinositol 4-kinase activity; 14-3-3 protein binding; ATP binding; kinase activity; nucleotide binding; transferase activity
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Biological Process:
phosphatidylinositol phosphorylation; phosphatidylinositol-mediated signaling; phosphorylation
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Reference #:
Q8BKC8
(UniProtKB)
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Alt. Names/Synonyms: AA437822; ESTM41; OTTMUSP00000021258; Phosphatidylinositol 4-kinase beta; phosphatidylinositol 4-kinase, catalytic, beta polypeptide; PI4K-beta; Pi4kb; PI4Kbeta; Pik4cb; PtdIns 4-kinase beta
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Gene Symbols: Pi4kb
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Molecular weight:
91,515 Da
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Basal Isoelectric point:
5.91
Predict pI for various phosphorylation states
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