PIK4CB Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking. Inhibited by wortmannin and adenosine. Increased kinase activity upon interaction with NCS1/FREQ. Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 3|3 F2.1
Cellular Component:  cytoplasm; endoplasmic reticulum; Golgi apparatus; Golgi membrane; membrane; mitochondrial outer membrane; mitochondrion
Molecular Function:  1-phosphatidylinositol 4-kinase activity; 14-3-3 protein binding; ATP binding; kinase activity; nucleotide binding; transferase activity
Biological Process:  inner ear development; lipid metabolic process; lysosome organization; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-mediated signaling; phosphorylation
Reference #:  Q8BKC8 (UniProtKB)
Alt. Names/Synonyms: AA437822; ESTM4; ESTM41; OTTMUSP00000021258; Phosphatidylinositol 4-kinase beta; phosphatidylinositol 4-kinase, catalytic, beta polypeptide; PI4K-beta; Pi4kb; PI4Kbeta; Pik4; Pik4cb; PtdIns 4-kinase beta
Gene Symbols: Pi4kb
Molecular weight: 91,515 Da
Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states
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PIK4CB

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene