PHF10 Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Belongs to the SAYP family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 17|17 A2
Cellular Component:  histone acetyltransferase complex; npBAF complex; nuclear chromatin; nucleus
Molecular Function:  histone acetyltransferase activity; histone binding; metal ion binding; protein binding
Biological Process:  negative regulation of transcription, DNA-templated; nervous system development; positive regulation of transcription by RNA polymerase II
Reference #:  Q9D8M7 (UniProtKB)
Alt. Names/Synonyms: 1810055P05Rik; AV024533; Baf4; BAF45a; BRG1-associated factor 45a; PHD finger protein 10; Phf10
Gene Symbols: Phf10
Molecular weight: 55,840 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene