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PHF10
Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Belongs to the SAYP family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of mouse Ortholog: 17|17 A2 |
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Cellular Component:
chromatin; kinetochore; npBAF complex; nuclear matrix; nucleoplasm; nucleus; RSC-type complex; SWI/SNF complex
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Molecular Function:
histone acetyltransferase activity; metal ion binding; protein binding; transcription coregulator activity
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Biological Process:
chromatin remodeling; negative regulation of DNA-templated transcription; nervous system development; positive regulation of cell differentiation; positive regulation of double-strand break repair; positive regulation of myoblast differentiation; positive regulation of stem cell population maintenance; positive regulation of T cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of G0 to G1 transition; regulation of G1/S transition of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; regulation of nucleotide-excision repair; regulation of transcription by RNA polymerase II
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Reference #:
Q9D8M7
(UniProtKB)
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Alt. Names/Synonyms: 1810055P05Rik; AV024533; Baf4; BAF45a; BRG1-associated factor 45a; PHD finger protein 10; Phf10
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Gene Symbols: Phf10
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Molecular weight:
55,840 Da
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Basal Isoelectric point:
6.19
Predict pI for various phosphorylation states
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