PHC3 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 3|3 A3
Cellular Component:  nucleus; PcG protein complex; PRC1 complex
Molecular Function:  DNA binding; metal ion binding; zinc ion binding
Biological Process:  multicellular organism development
Reference #:  Q8CHP6 (UniProtKB)
Alt. Names/Synonyms: E030046K01Rik; EDR; Edr3; HPH; Hph3; OTTMUSP00000027500; Phc3; polyhomeotic 3; polyhomeotic-like 3; polyhomeotic-like 3 (Drosophila); Polyhomeotic-like protein 3
Gene Symbols: Phc3
Molecular weight: 105,353 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene