PHC2 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of mouse Ortholog: 4 D2.2|4 62.12 cM
Cellular Component:  heterochromatin; nucleoplasm; nucleus; PcG protein complex; PRC1 complex
Molecular Function:  chromatin binding; DNA binding; histone binding; identical protein binding; metal ion binding; protein binding; zinc ion binding
Biological Process:  multicellular organism development; negative regulation of DNA-templated transcription; spermatogenesis
Reference #:  Q9QWH1 (UniProtKB)
Alt. Names/Synonyms: A3galt2; AA415044; D130050K19Rik; D4Ertd810; D4Ertd810e; early development regulator 2; early development regulator 2 (homolog of polyhomeotic 2); Early development regulatory protein 2; Edr; Edr2; Mph; mPH2; OTTMUSP00000009839; p36; Ph2; Phc2; polyhomeotic 2; polyhomeotic 2 protein; polyhomeotic-like 2; polyhomeotic-like 2 (Drosophila); Polyhomeotic-like protein 2; RP23-467J23.1
Gene Symbols: Phc2
Molecular weight: 89,799 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
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PHC2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene