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hnRNP E2
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation. (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation. Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. Detected in all tissues examined. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing; RNA-binding |
| Chromosomal Location of mouse Ortholog: 15 F3|15 57.61 cM |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm; nucleus; postsynaptic density; ribonucleoprotein complex
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Molecular Function:
C-rich single-stranded DNA binding; DNA binding; enzyme binding; mRNA binding; nucleic acid binding; protein binding; RNA binding; single-stranded DNA binding; ubiquitin protein ligase binding
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Biological Process:
defense response to virus; immune system process; innate immune response; IRES-dependent viral translational initiation; negative regulation of defense response to virus; negative regulation of innate immune response; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of gene expression; regulation of RNA metabolic process; viral RNA genome replication
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Reference #:
Q61990
(UniProtKB)
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Alt. Names/Synonyms: alph; Alpha-CP2; alphaCP-2; AW412548; CBP; CTBP; heterogeneous nuclear ribonucleoprotein X; hnRNP E2; hnRNP X; Hnrnpx; Hnrpx; MGC107004; Pcbp2; poly(rC) binding protein 2; Poly(rC)-binding protein 2; Putative heterogeneous nuclear ribonucleoprotein X
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Gene Symbols: Pcbp2
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Molecular weight:
38,222 Da
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Basal Isoelectric point:
6.33
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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