hnRNP E2 Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation. (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation. Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. Detected in all tissues examined. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 15 F3|15 57.61 cM
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; postsynaptic density
Molecular Function:  C-rich single-stranded DNA binding; DNA binding; enzyme binding; nucleic acid binding; protein binding; RNA binding; ubiquitin protein ligase binding
Biological Process:  defense response to virus; immune system process; innate immune response; IRES-dependent viral translational initiation; negative regulation of defense response to virus; proteasome-mediated ubiquitin-dependent protein catabolic process; viral RNA genome replication
Reference #:  Q61990 (UniProtKB)
Alt. Names/Synonyms: Alpha-CP2; alphaCP-2; AW412548; CBP; CTBP; heterogeneous nuclear ribonucleoprotein X; hnRNP X; Hnrnpx; Hnrpx; MGC107004; Pcbp2; poly(rC) binding protein 2; Poly(rC)-binding protein 2; Putative heterogeneous nuclear ribonucleoprotein X
Gene Symbols: Pcbp2
Molecular weight: 38,222 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

hnRNP E2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene