G-alpha 11 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Belongs to the G-alpha family. G(q) subfamily. Expressed in testis. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q)
Chromosomal Location of human Ortholog: 19p13.3
Cellular Component:  cytoplasm; photoreceptor outer segment; plasma membrane
Molecular Function:  GTP binding; metal ion binding; protein binding
Biological Process:  cellular response to pH; developmental pigmentation; entrainment of circadian clock; G protein-coupled acetylcholine receptor signaling pathway; G protein-coupled receptor signaling pathway; heart development; phototransduction, visible light; platelet activation; regulation of melanocyte differentiation; signal transduction; skeletal system development
Disease: Hypocalcemia, Autosomal Dominant 2; Hypocalciuric Hypercalcemia, Familial, Type Ii
Reference #:  P29992 (UniProtKB)
Alt. Names/Synonyms: FBH; FBH2; FHH2; G alpha-11; G protein subunit alpha 11; G-alpha 11; G-protein subunit alpha-11; GA11; GNA-11; GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding protein G(y) subunit alpha; Guanine nucleotide-binding protein subunit alpha-11; guanine nucleotide-binding protein, Gq class, GNA11; HHC2; HYPOC2
Gene Symbols: GNA11
Molecular weight: 42,123 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Phospholipase Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

G-alpha 11

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB