hnRNP E1 Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Translation
Chromosomal Location of Human Ortholog: 6|6 D1
Cellular Component:  cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; nuclear speck; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; mRNA binding; nucleic acid binding; protein binding; RNA binding; sequence-specific single stranded DNA binding; single-stranded DNA binding; translation activator activity
Biological Process:  mRNA processing; positive regulation of transcription by RNA polymerase II; viral RNA genome replication
Reference #:  P60335 (UniProtKB)
Alt. Names/Synonyms: [a]CP-1; Alpha-CP1; alphaCP-1; Heterogeneous nuclear ribonucleoprotein E1; hnRNP E1; hnRNP-E1; OTTMUSP00000026004; Pcbp1; poly(rC) binding protein 1; Poly(rC)-binding protein 1; WBP17
Gene Symbols: Pcbp1
Molecular weight: 37,498 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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hnRNP E1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene