PARVB Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. Belongs to the parvin family. Expressed predominantly in heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 15|15 E2
Cellular Component:  actin cytoskeleton; cell junction; cell projection; cytoplasm; cytoskeleton; focal adhesion; lamellipodium; membrane; plasma membrane
Molecular Function:  actin binding; protein binding
Biological Process:  actin cytoskeleton reorganization; cell adhesion; cell projection assembly; establishment or maintenance of cell polarity; establishment or maintenance of cell polarity regulating cell shape; lamellipodium assembly; substrate adhesion-dependent cell spreading
Reference #:  Q9ES46 (UniProtKB)
Alt. Names/Synonyms: aff; affixin; AI595373; AW742462; Beta-parvin; D15Gsk; D15Gsk1; OTTMUSP00000032032; Parvb; parvin, beta
Gene Symbols: Parvb
Molecular weight: 41,669 Da
Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein