PAICS In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Ligase; Lyase; Nucleotide Metabolism - purine
Chromosomal Location of mouse Ortholog: 5|5 C3.3
Cellular Component:  cytoplasm
Molecular Function:  5-amino-4-imidazole carboxylate lyase activity; ATP binding; carboxy-lyase activity; catalytic activity; identical protein binding; ligase activity; lyase activity; nucleotide binding; phosphoribosylaminoimidazole carboxylase activity; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Biological Process:  'de novo' AMP biosynthetic process; 'de novo' IMP biosynthetic process; 'de novo' XMP biosynthetic process; GMP biosynthetic process; metabolic process; purine nucleobase biosynthetic process; purine nucleotide biosynthetic process
Reference #:  Q9DCL9 (UniProtKB)
Alt. Names/Synonyms: 2610511I09Rik; ADE2H; ADE2H1; AIR carboxylase; AIRC; Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase; Multifunctional protein ADE2; Paics; PAIS; Phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase; Phosphoribosylaminoimidazole-succinocarboxamide synthase; PUR6; SAICAR synthetase
Gene Symbols: Paics
Molecular weight: 47,006 Da
Basal Isoelectric point: 6.94  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein