PAICS
In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: EC 4.1.1.21; EC 6.3.2.6; Ligase; Lyase; Nucleotide Metabolism - purine |
Chromosomal Location of mouse Ortholog: 5|5 C3.3 |
Cellular Component:
cytoplasm
|
Molecular Function:
5-amino-4-imidazole carboxylate lyase activity; ATP binding; carboxy-lyase activity; catalytic activity; identical protein binding; ligase activity; lyase activity; nucleotide binding; phosphoribosylaminoimidazole carboxylase activity; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
|
Biological Process:
'de novo' AMP biosynthetic process; 'de novo' IMP biosynthetic process; 'de novo' XMP biosynthetic process; GMP biosynthetic process; metabolic process; purine nucleobase biosynthetic process; purine nucleotide biosynthetic process
|
Reference #:
Q9DCL9
(UniProtKB)
|
Alt. Names/Synonyms: 2610511I09Rik; ADE2H; ADE2H1; AIR carboxylase; AIRC; Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase; Multifunctional protein ADE2; Paics; PAIS; Phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase; Phosphoribosylaminoimidazole-succinocarboxamide synthase; PUR6; SAICAR synthetase
|
Gene Symbols: Paics
|
Molecular weight:
47,006 Da
|
Basal Isoelectric point:
6.94
Predict pI for various phosphorylation states
|