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PAICS
In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 4.1.1.21; EC 6.3.2.6; Ligase; Lyase; Nucleotide Metabolism - purine |
| Chromosomal Location of mouse Ortholog: 5|5 C3.3 |
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Cellular Component:
cytoplasm
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Molecular Function:
5-amino-4-imidazole carboxylate lyase activity; ATP binding; carboxy-lyase activity; catalytic activity; identical protein binding; ligase activity; lyase activity; nucleotide binding; phosphoribosylaminoimidazole carboxylase activity; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
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Biological Process:
'de novo' AMP biosynthetic process; 'de novo' IMP biosynthetic process; 'de novo' XMP biosynthetic process; GMP biosynthetic process; metabolic process; purine nucleobase biosynthetic process; purine nucleotide biosynthetic process
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Reference #:
Q9DCL9
(UniProtKB)
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Alt. Names/Synonyms: 2610511I09Rik; ADE2H; ADE2H1; AIR carboxylase; AIRC; Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase; Multifunctional protein ADE2; Paics; PAIS; Phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase; Phosphoribosylaminoimidazole-succinocarboxamide synthase; PUR6; SAICAR synthetase
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Gene Symbols: Paics
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Molecular weight:
47,006 Da
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Basal Isoelectric point:
6.94
Predict pI for various phosphorylation states
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