OSBP Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability. Belongs to the OSBP family. Widely expressed. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding
Chromosomal Location of Human Ortholog: 19 A|19 8.58 cM
Cellular Component:  cell junction; cytoplasm; cytosol; endoplasmic reticulum; Golgi apparatus; Golgi membrane; intracellular membrane-bounded organelle; membrane; nucleolus; nucleoplasm; nucleus; perinuclear endoplasmic reticulum; perinuclear region of cytoplasm; plasma membrane; trans-Golgi network
Molecular Function:  lipid binding; phosphatidylinositol-4-phosphate binding; protein binding; protein domain specific binding; sterol binding; sterol transporter activity
Biological Process:  intracellular cholesterol transport; lipid transport; positive regulation of growth of symbiont in host; sterol transport
Reference #:  Q3B7Z2 (UniProtKB)
Alt. Names/Synonyms: 1110018F06Rik; AW559088; Kiaa4220; mKIAA4220; Osbp; OSBP1; oxysterol binding protein; Oxysterol-binding protein 1
Gene Symbols: Osbp
Molecular weight: 88,797 Da
Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene