NIF3L1 May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation. Belongs to the GTP cyclohydrolase I type 2/NIF3 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.5.4.16; Transcription, coactivator/corepressor
Chromosomal Location of mouse Ortholog: 1|1 C1.3
Cellular Component:  cytoplasm; mitochondrion; nucleus
Molecular Function:  identical protein binding; protein binding; transcription factor binding
Biological Process:  negative regulation of nucleic acid-templated transcription; neuron differentiation; positive regulation of transcription, DNA-templated
Reference #:  Q9EQ80 (UniProtKB)
Alt. Names/Synonyms: 1110030G24Rik; GTP cyclohydrolase I; MGC107114; Ngg1 interacting factor 3 homolog-like 1; Ngg1 interacting factor 3-like 1 (S. pombe); NIF3-like protein 1; NIF3L; Nif3l1; OTTMUSP00000024667; putative GTP cyclohydrolase 1 type 2 Nif3l1
Gene Symbols: Nif3l1
Molecular weight: 41,746 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
Select Structure to View Below

NIF3L1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene