NMDAR2A Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kinetics than channels formed by GRIN1 and GRIN2B. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2A/GRIN2A subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 16p13.2
Cellular Component:  cell junction; cell surface; endoplasmic reticulum; glutamatergic synapse; integral component of plasma membrane; integral component of postsynaptic density membrane; neuron projection; NMDA selective glutamate receptor complex; plasma membrane; postsynaptic density; presynaptic membrane; synaptic membrane; synaptic vesicle
Molecular Function:  amyloid-beta binding; glutamate-gated calcium ion channel activity; NMDA glutamate receptor activity; protein binding; zinc ion binding
Biological Process:  activation of cysteine-type endopeptidase activity; brain development; calcium ion transmembrane import into cytosol; calcium-mediated signaling; chemical synaptic transmission; directional locomotion; dopamine metabolic process; excitatory chemical synaptic transmission; glutamate receptor signaling pathway; ionotropic glutamate receptor signaling pathway; learning or memory; memory; negative regulation of protein catabolic process; neurogenesis; positive regulation of apoptotic process; positive regulation of long-term synaptic potentiation; protein localization to postsynaptic membrane; regulation of NMDA receptor activity; regulation of sensory perception of pain; regulation of synaptic plasticity; response to amphetamine; response to ethanol; response to wounding; sensory perception of pain; serotonin metabolic process; sleep; startle response; visual learning
Disease: Epilepsy, Focal, With Speech Disorder And With Or Without Mental Retardation
Reference #:  Q12879 (UniProtKB)
Alt. Names/Synonyms: EPND; FESD; GluN2A; Glutamate [NMDA] receptor subunit epsilon-1; glutamate ionotropic receptor NMDA type subunit 2A; Glutamate receptor ionotropic, NMDA 2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; GRIN2A; hNR2A; LKS; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NMDA receptor subtype 2A; NMDAR2A; NMDE1; NR2A
Gene Symbols: GRIN2A
Molecular weight: 165,283 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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