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NEK11
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Poorly expressed in cerebellum, trachea, lung, appendix, and uterus. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; NEK family; NEK11 subfamily; Nucleolus; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: 9|9 F1 |
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Cellular Component:
nucleolus; nucleoplasm; nucleus
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Molecular Function:
ATP binding; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
cell cycle; intracellular signal transduction; mitotic intra-S DNA damage checkpoint signaling; phosphorylation; protein phosphorylation; regulation of mitotic cell cycle phase transition
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Reference #:
Q8C0Q4
(UniProtKB)
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Alt. Names/Synonyms: 4932416N14Rik; Nek11; Never in mitosis A-related kinase 11; NIMA (never in mitosis gene a)-related expressed kinase 11; NIMA-related kinase 11; NimA-related protein kinase 11; OTTMUSP00000028752; Serine/threonine-protein kinase Nek11
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Gene Symbols: Nek11
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Molecular weight:
71,648 Da
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Basal Isoelectric point:
5.26
Predict pI for various phosphorylation states
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