MTA2 May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Deacetylase; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of mouse Ortholog: 19|19 A
Cellular Component:  histone deacetylase complex; nucleoplasm; nucleus; NuRD complex; transcription factor complex
Molecular Function:  chromatin binding; DNA binding; histone deacetylase activity; histone deacetylase binding; metal ion binding; protein binding; RNA polymerase II repressing transcription factor binding; RNA polymerase II transcription factor binding; sequence-specific DNA binding; transcription coactivator activity; transcription coregulator activity; transcription corepressor activity; transcription regulatory region DNA binding; zinc ion binding
Biological Process:  chromatin remodeling; DNA methylation; DNA packaging; histone deacetylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; regulation of fibroblast migration; regulation of transcription, DNA-templated
Reference #:  Q9R190 (UniProtKB)
Alt. Names/Synonyms: AW550797; Mata1l1; metastais-associated gene family, member 2; metastasis associated 1-like 1; Metastasis-associated 1-like 1; metastasis-associated gene family, member 2; metastasis-associated protein 2; Metastasis-associated protein MTA2; mmta; mmta2; Mta1; Mta1l1; Mta2; OTTMUSP00000018855
Gene Symbols: Mta2
Molecular weight: 75,030 Da
Basal Isoelectric point: 9.71  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MTA2

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA