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MTA2
May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Deacetylase; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor |
| Chromosomal Location of mouse Ortholog: 19|19 A |
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Cellular Component:
chromosome, telomeric region; histone deacetylase complex; nucleoplasm; nucleus; NuRD complex; transcription regulator complex
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Molecular Function:
chromatin binding; DNA binding; histone deacetylase activity; histone deacetylase binding; metal ion binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription coactivator activity; transcription coregulator activity; transcription corepressor activity
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Biological Process:
chromatin remodeling; chromosome organization; DNA methylation; histone deacetylation; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of cell fate specification; regulation of DNA-templated transcription; regulation of fibroblast migration; regulation of stem cell differentiation
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Reference #:
Q9R190
(UniProtKB)
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Alt. Names/Synonyms: AW550797; Mata1l1; metastais-associated gene family, member 2; metastasis associated 1-like 1; Metastasis-associated 1-like 1; metastasis-associated gene family, member 2; metastasis-associated protein 2; Metastasis-associated protein MTA2; mmta; mmta2; Mta1; Mta1l1; Mta2; OTTMUSP00000018855
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Gene Symbols: Mta2
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Molecular weight:
75,030 Da
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Basal Isoelectric point:
9.71
Predict pI for various phosphorylation states
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CST Pathways:
Protein Acetylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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