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MSL3L1
Has a role in chromatin remodeling and transcriptional regulation. Has a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. Expressed in many tissues including liver, pancreas, heart, lung, kidney, skeletal muscle, brain, and placenta, with highest expression in skeletal muscle and heart. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor |
| Chromosomal Location of mouse Ortholog: X|X F5 |
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Cellular Component:
MSL complex; NuA4 histone acetyltransferase complex; nucleus
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Molecular Function:
DNA binding; histone H4K16 acetyltransferase activity; methylated histone binding
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Biological Process:
chromatin organization; histone H2A acetylation; histone H4-K16 acetylation; positive regulation of DNA-templated transcription; regulation of DNA-templated transcription; regulation of dosage compensation by inactivation of X chromosome
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Reference #:
Q9WVG9
(UniProtKB)
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Alt. Names/Synonyms: AU018931; Male-specific lethal 3 homolog; male-specific lethal 3 homolog (Drosophila); Male-specific lethal-3 homolog 1; Male-specific lethal-3 protein-like 1; MS3L1; Msl; MSL complex subunit 3; Msl3; MSL3-like 1; Msl31; Msl3l1; OTTMUSP00000021100
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Gene Symbols: Msl3
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Molecular weight:
60,292 Da
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Basal Isoelectric point:
9.59
Predict pI for various phosphorylation states
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