MSH6 Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-- Belongs to the DNA mismatch repair MutS family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 17 E4|17 57.87 cM
Cellular Component:  chromosome; cytosol; Golgi apparatus; intracellular membrane-bounded organelle; mismatch repair complex; MutSalpha complex; nuclear chromatin; nucleoplasm; nucleus
Molecular Function:  ATP binding; chromatin binding; damaged DNA binding; DNA binding; DNA-dependent ATPase activity; enzyme binding; four-way junction DNA binding; guanine/thymine mispair binding; methylated histone binding; mismatched DNA binding; nucleotide binding
Biological Process:  cellular response to DNA damage stimulus; determination of adult lifespan; DNA repair; interstrand cross-link repair; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; isotype switching; maintenance of DNA repeat elements; meiotic mismatch repair; mismatch repair; negative regulation of DNA endoreduplication; negative regulation of DNA recombination; positive regulation of helicase activity; pyrimidine dimer repair; response to UV; somatic hypermutation of immunoglobulin genes; somatic recombination of immunoglobulin gene segments
Reference #:  P54276 (UniProtKB)
Alt. Names/Synonyms: AU044881; AW550279; DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; GTMBP; Msh6; mutS homolog 6 (E. coli); MutS-alpha 160 kDa subunit; p160
Gene Symbols: Msh6
Molecular weight: 151,084 Da
Basal Isoelectric point: 6.31  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MSH6

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene