FRS2 Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 12q15
Cellular Component:  cell-cell adherens junction; cytosol; endomembrane system; integral component of plasma membrane; membrane; plasma membrane
Molecular Function:  fibroblast growth factor receptor binding; neurotrophin TRKA receptor binding; phosphatase activator activity; protein binding; transmembrane receptor protein tyrosine kinase adaptor activity
Biological Process:  activation of MAPK activity; activation of MAPKK activity; anterior/posterior axis specification, embryo; axon guidance; fibroblast growth factor receptor signaling pathway; forebrain development; G protein-coupled receptor signaling pathway; gastrulation with mouth forming second; lens fiber cell development; MAPK cascade; negative regulation of cardiac muscle cell differentiation; neuroblast proliferation; neurotrophin TRK receptor signaling pathway; optic placode formation involved in camera-type eye formation; organ induction; positive regulation of protein kinase B signaling; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; regulation of apoptotic process; regulation of epithelial cell proliferation; regulation of ERK1 and ERK2 cascade; transmembrane receptor protein tyrosine phosphatase signaling pathway; ventricular septum development
Reference #:  Q8WU20 (UniProtKB)
Alt. Names/Synonyms: FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; Fibroblast growth factor receptor substrate 2; FRS2; FRS2A; FRS2alpha; SNT; SNT-1; SNT1; Suc1-associated neurotrophic factor target 1
Gene Symbols: FRS2
Molecular weight: 57,029 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
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Protein Structure Not Found.

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