MECP2 Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). Present in all adult somatic tissues tested. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: X A7.3|X 37.63 cM
Cellular Component:  centrosome; chromatin; cytoplasm; cytosol; glutamatergic synapse; heterochromatin; nuclear chromatin; nucleus; protein-containing complex
Molecular Function:  chromatin binding; chromatin DNA binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded methylated DNA binding; enzyme binding; four-way junction DNA binding; histone deacetylase binding; methyl-CpG binding; mRNA binding; promoter-specific chromatin binding; protein binding; protein domain specific binding; protein N-terminus binding; siRNA binding; transcription factor binding; unmethylated CpG binding
Biological Process:  adult locomotory behavior; behavioral fear response; brain development; cardiolipin metabolic process; catecholamine secretion; cellular biogenic amine metabolic process; cellular response to isoquinoline alkaloid; cellular response to potassium ion; cerebellum development; chemical synaptic transmission; chromatin silencing; dendrite development; excitatory postsynaptic potential; glucocorticoid metabolic process; glutamine metabolic process; histone acetylation; histone methylation; inositol metabolic process; learning; long-term memory; long-term synaptic potentiation; memory; mitochondrial electron transport, ubiquinol to cytochrome c; mitotic spindle organization; multicellular organismal response to stress; negative regulation of angiogenesis; negative regulation of astrocyte differentiation; negative regulation of blood vessel endothelial cell migration; negative regulation of dendrite extension; negative regulation of dendritic spine development; negative regulation of gene expression; negative regulation of neuron apoptotic process; negative regulation of primary miRNA processing; negative regulation of protein binding; negative regulation of smooth muscle cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; negative regulation of transcription, DNA-templated; neurological system process involved in regulation of systemic arterial blood pressure; neuromuscular process; neuromuscular process controlling posture; neuron differentiation; neuron maturation; neuron projection development; pathogenesis; phosphatidylcholine metabolic process; positive regulation of anterograde dense core granule transport; positive regulation of branching morphogenesis of a nerve; positive regulation of cell proliferation; positive regulation of dendrite extension; positive regulation of dendritic spine development; positive regulation of DNA methylation; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of histone H3-K9 trimethylation; positive regulation of microtubule nucleation; positive regulation of retrograde dense core granule transport; positive regulation of synaptic plasticity; positive regulation of transcription, DNA-templated; post-embryonic development; proprioception; protein localization; regulation of DNA methylation; regulation of gene expression; regulation of gene expression by genetic imprinting; regulation of gene expression, epigenetic; regulation of respiratory gaseous exchange by neurological system process; regulation of synapse organization; regulation of synaptic plasticity; regulation of transcription, DNA-templated; respiratory gaseous exchange; response to cocaine; response to hypoxia; response to radiation; sensory perception of pain; social behavior; startle response; synapse assembly; ventricular system development; visual learning
Reference #:  Q9Z2D6 (UniProtKB)
Alt. Names/Synonyms: 1500041B07Rik; BB130002; D630021H01Rik; Mbd5; MeCp-2 protein; MeCp2; methyl CpG binding protein 2; Methyl-CpG-binding protein 2; OTTMUSP00000019241; OTTMUSP00000019680; WBP10
Gene Symbols: Mecp2
Molecular weight: 52,307 Da
Basal Isoelectric point: 9.96  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene