MAT1A Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. Belongs to the AdoMet synthase family. Expressed in liver. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; EC; Other Amino Acids Metabolism - selenoamino acid; Transferase
Chromosomal Location of Human Ortholog: 14|14 B
Cellular Component:  cytosol; nuclear matrix
Molecular Function:  ADP binding; amino acid binding; ATP binding; identical protein binding; magnesium ion binding; metal ion binding; methionine adenosyltransferase activity; nucleotide binding; protein dimerization activity; protein homodimerization activity; transferase activity
Biological Process:  methionine catabolic process; one-carbon metabolic process; protein homooligomerization; protein homotetramerization; protein tetramerization; S-adenosylmethionine biosynthetic process
Reference #:  Q91X83 (UniProtKB)
Alt. Names/Synonyms: AdoM; AdoMet; AdoMet synthase 1; adoMet synthetase 1; AI046368; Ams; MAT; MAT 1; Mat1a; MATA1; Methionine adenosyltransferase 1; methionine adenosyltransferase I, alpha; METK1; S-adenosylmethionine synthase; S-adenosylmethionine synthase isoform type-1; S-adenosylmethionine synthetase isoform type-1; SAMS; SAMS1
Gene Symbols: Mat1a
Molecular weight: 43,509 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene