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MASTL
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: AGC group; EC 2.7.11.1; Kinase, protein; MAST family; MASTL subfamily; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: 2|2 A3 |
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Cellular Component:
centrosome; cleavage furrow; cytoplasm; cytoskeleton; nucleoplasm; nucleus
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Molecular Function:
ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
cell cycle; cell division; female meiosis II; G2/M transition of mitotic cell cycle; intracellular signal transduction; mitotic cell cycle; negative regulation of phosphoprotein phosphatase activity; peptidyl-serine phosphorylation; phosphorylation; positive regulation of ubiquitin protein ligase activity; protein phosphorylation; regulation of cell cycle
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Reference #:
Q8C0P0
(UniProtKB)
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Alt. Names/Synonyms: 2700091H24Rik; C88295; greatwall; Gw; Gwl; MAST-L; Mastl; MGC117975; microtubule associated serine/threonine kinase-like; Microtubule-associated serine/threonine-protein kinase-like; OTTMUSP00000012380; Serine/threonine-protein kinase greatwall; THC2
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Gene Symbols: Mastl
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Molecular weight:
95,975 Da
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Basal Isoelectric point:
5.36
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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