MASTL Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. Defects in MASTL are the cause of thrombocytopenia type 2 (THC2). Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC 2.7.11.1; Kinase, protein; MAST family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 2|2 A3
Cellular Component:  centrosome; cleavage furrow; cytoplasm; cytoskeleton; nucleoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell cycle; cell division; female meiosis II; G2/M transition of mitotic cell cycle; intracellular signal transduction; mitotic cell cycle; negative regulation of phosphoprotein phosphatase activity; peptidyl-serine phosphorylation; phosphorylation; positive regulation of ubiquitin protein ligase activity; protein phosphorylation; regulation of cell cycle
Reference #:  Q8C0P0 (UniProtKB)
Alt. Names/Synonyms: 2700091H24Rik; C88295; greatwall; Gw; Gwl; Mastl; MGC117975; microtubule associated serine/threonine kinase-like; Microtubule-associated serine/threonine-protein kinase-like; OTTMUSP00000012380; Serine/threonine-protein kinase greatwall; THC2
Gene Symbols: Mastl
Molecular weight: 95,975 Da
Basal Isoelectric point: 5.36  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MASTL

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene