MAK Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors. Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RCK family
Chromosomal Location of Human Ortholog: 13 A3.3|13 20.25 cM
Cellular Component:  axoneme; cell projection; centrosome; ciliary tip; cilium; cytoplasm; cytoskeleton; midbody; mitotic spindle; motile cilium; nucleus; photoreceptor connecting cilium; photoreceptor inner segment; photoreceptor outer segment
Molecular Function:  ATP binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transcription coactivator activity; transferase activity
Biological Process:  cilium assembly; intracellular signal transduction; intraciliary transport; negative regulation of non-motile cilium assembly; phosphorylation; photoreceptor cell maintenance; protein autophosphorylation; protein phosphorylation; regulation of gene expression
Reference #:  Q04859 (UniProtKB)
Alt. Names/Synonyms: A930010O05Rik; Mak; Male germ cell-associated kinase; Protein kinase RCK; Rck; Serine/threonine-protein kinase MAK
Gene Symbols: Mak
Molecular weight: 70,080 Da
Basal Isoelectric point: 9.67  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA