MAD1L1 a component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Expressed weakly at G0/G1 and highly at late S and G2/M phase. Induced by p53. Becomes hyperphosphorylated in late S through M phases or after mitotic spindle damage. Two alternatively spliced isoforms have been described. Defects in MAD1L1 are involved in the development and/or progression of various types of cancer. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytoskeletal
Chromosomal Location of Human Ortholog: 5 G2|5 78.82 cM
Cellular Component:  chromosome; chromosome, centromeric region; cytoplasm; cytoskeleton; kinetochore; mitotic spindle; nuclear envelope; nuclear pore nuclear basket; nucleus; spindle pole
Molecular Function:  identical protein binding; kinetochore binding
Biological Process:  attachment of mitotic spindle microtubules to kinetochore; cell cycle; cell division; mitotic spindle assembly checkpoint; negative regulation of T cell proliferation; regulation of metaphase plate congression; regulation of mitotic cell cycle phase transition; thymus development
Reference #:  Q9WTX8 (UniProtKB)
Alt. Names/Synonyms: AI173502; AW550425; Mad1; MAD1-like protein 1; Mad1l1; MD1L1; mitotic arrest deficient 1-like 1; Mitotic arrest deficient 1-like protein 1; Mitotic spindle assembly checkpoint protein MAD1
Gene Symbols: Mad1l1
Molecular weight: 83,541 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene