LRRC16 Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments. Plays a role in lamellipodial protrusion formations and cell migration. Belongs to the CARMIL family. Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 13|13 A3.1
Cellular Component:  cell leading edge; cell projection; cytoplasm; cytoskeleton; cytosol; filamentous actin; lamellipodium; macropinosome; membrane; nuclear speck; nucleus; plasma membrane
Molecular Function:  protein-containing complex binding
Biological Process:  actin filament network formation; barbed-end actin filament uncapping; cell migration; lamellipodium assembly; macropinocytosis; negative regulation of barbed-end actin filament capping; positive regulation of actin filament polymerization; positive regulation of cell migration; positive regulation of lamellipodium organization; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; ruffle organization; urate metabolic process
Reference #:  Q6EDY6 (UniProtKB)
Alt. Names/Synonyms: 1110037D04Rik; AI425970; capping protein regulator and myosin 1 linker 1; Capping protein regulator and myosin 1 linker protein 1; Capping protein, Arp2/3 and myosin-I linker homolog 1; Capping protein, Arp2/3 and myosin-I linker protein 1; CARL1; CARMIL; CARMIL homolog; Carmil1; CARML1; D130057M20; F-actin-uncapping protein LRRC16A; leucine rich repeat containing 16; leucine rich repeat containing 16A; leucine-rich repeat-containing protein 16A; LR16A; Lrr; Lrrc16; Lrrc16a; OTTMUSP00000000557
Gene Symbols: Lrrc16a
Molecular weight: 151,860 Da
Basal Isoelectric point: 7.98  Predict pI for various phosphorylation states
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LRRC16

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene