LRRC16
Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments. Plays a role in lamellipodial protrusion formations and cell migration. Belongs to the CARMIL family. Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Unknown function |
Chromosomal Location of mouse Ortholog: 13|13 A3.1 |
Cellular Component:
cell leading edge; cell projection; cytoplasm; cytoskeleton; cytosol; filamentous actin; lamellipodium; macropinosome; membrane; nuclear speck; nucleoplasm; plasma membrane
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Molecular Function:
protein-containing complex binding
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Biological Process:
actin filament network formation; barbed-end actin filament uncapping; cell migration; lamellipodium assembly; macropinocytosis; negative regulation of barbed-end actin filament capping; positive regulation of actin filament polymerization; positive regulation of cell migration; positive regulation of lamellipodium organization; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; regulation of Arp2/3 complex-mediated actin nucleation; ruffle organization; urate metabolic process
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Reference #:
Q6EDY6
(UniProtKB)
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Alt. Names/Synonyms: 1110037D04Rik; AI425970; capping protein regulator and myosin 1 linker 1; Capping protein regulator and myosin 1 linker protein 1; Capping protein, Arp2/3 and myosin-I linker homolog 1; Capping protein, Arp2/3 and myosin-I linker protein 1; CARL1; CARMIL; CARMIL homolog; Carmil1; CARML1; D130057M20; F-actin-uncapping protein LRRC16A; leucine rich repeat containing 16; leucine rich repeat containing 16A; leucine-rich repeat-containing protein 16A; LR16A; Lrr; Lrrc16; Lrrc16a; OTTMUSP00000000557
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Gene Symbols: Carmil1
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Molecular weight:
151,860 Da
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Basal Isoelectric point:
7.98
Predict pI for various phosphorylation states
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