| KPNA2 Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the importin alpha family. Expressed ubiquitously. Note: This description may include information from UniProtKB. |
| Protein type: Karyopherin; Nuclear import; Nucleoporin |
| Chromosomal Location of Human Ortholog: 11|11 E1 |
| Cellular Component: cytoplasmic stress granule; cytosol; extrinsic component of postsynaptic specialization membrane; glutamatergic synapse; nucleoplasm |
| Molecular Function: histone deacetylase binding; nuclear import signal receptor activity; nuclear localization sequence binding; protein binding; repressing transcription factor binding |
| Biological Process: entry of viral genome into host nucleus through nuclear pore complex via importin; NLS-bearing protein import into nucleus; positive regulation of viral life cycle; postsynapse to nucleus signaling pathway; protein import into nucleus |
| Reference #: P52293 (UniProtKB) |
| Alt. Names/Synonyms: 2410044B12Rik; IMA1; IMA2; importin alpha 1; Importin alpha P1; Importin subunit alpha-1; Importin subunit alpha-2; IPOA1; karyopherin (importin) alpha 2; Karyopherin subunit alpha-2; Kpna2; m-im; m-importin-alpha-P1; MGC91246; OTTMUSP00000003739; pen; Pendulin; Pore targeting complex 58 kDa subunit; PTAC58; RAG cohort protein 1; Rch; Rch1; SRP1-alpha |
| Gene Symbols: Kpna2 |
| Molecular weight: 57,928 Da |
| Basal Isoelectric point: 5.49 Predict pI for various phosphorylation states |
| CST Pathways: Protein Acetylation |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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KPNA2 |
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| Cross-references to other databases:
STRING
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Reactome
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BioGPS
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Pfam
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