JMJD2A Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. Belongs to the JHDM3 histone demethylase family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 4 D2.1|4 54.31 cM
Cellular Component:  cytoplasm; cytosol; fibrillar center; histone methyltransferase complex; nucleus; pericentric heterochromatin
Molecular Function:  dioxygenase activity; histone demethylase activity; histone demethylase activity (H3-K36 specific); histone demethylase activity (H3-K9 specific); metal ion binding; methylated histone binding; oxidoreductase activity; ubiquitin protein ligase binding; zinc ion binding
Biological Process:  cardiac muscle hypertrophy in response to stress; chromatin organization; chromatin remodeling; histone demethylation; histone H3-K36 demethylation; histone H3-K9 demethylation; negative regulation of astrocyte differentiation; negative regulation of autophagy; negative regulation of cell death; negative regulation of gene expression; negative regulation of histone H3-K9 trimethylation; negative regulation of transcription, DNA-templated; positive regulation of gene expression; positive regulation of neuron differentiation
Reference #:  Q8BW72 (UniProtKB)
Alt. Names/Synonyms: [histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A; D4Ertd222; D4Ertd222e; JHDM3; Jhdm3a; JmjC domain-containing histone demethylation protein 3A; Jmjd2; Jmjd2a; jumonji domain containing 2A; Jumonji domain-containing protein 2A; Kdm4a; Kiaa0677; lysine (K)-specific demethylase 4A; Lysine-specific demethylase 4A; MGC28562; mKIAA0677; OTTMUSP00000009080
Gene Symbols: Kdm4a
Molecular weight: 120,334 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene