IP3R2 Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA. Belongs to the InsP3 receptor family. Isoform Short is found in skeletal muscle and heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 6 G3|6 77.7 cM
Cellular Component:  axon; cell cortex; cytoplasm; cytoplasmic vesicle membrane; endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; membrane; myelin sheath; nucleus; plasma membrane; receptor complex; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; secretory granule membrane
Molecular Function:  calcium channel activity; calcium ion binding; calcium-release channel activity; inositol 1,4,5 trisphosphate binding; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; ion channel activity; phosphatidylinositol binding; protein binding; scaffold protein binding
Biological Process:  calcium ion transmembrane transport; calcium ion transport; cellular response to cAMP; cellular response to ethanol; ion transport; release of sequestered calcium ion into cytosol; response to hypoxia; transmembrane transport
Reference #:  Q9Z329 (UniProtKB)
Alt. Names/Synonyms: AI649341; inositol 1,4,5-triphosphate receptor 2; inositol 1,4,5-triphosphate receptor 5; Inositol 1,4,5-trisphosphate receptor type 2; Inositol 1,4,5-trisphosphate type V receptor; inositol trisphosphate receptor type 2; InsP3R-2; InsP3R-5; InsP3R2; IP3 receptor; IP3 receptor isoform 2; IP3R 2; Ip3r2; Itpr2; Itpr5; OTTMUSP00000031144; OTTMUSP00000031145; Type 2 inositol 1,4,5-trisphosphate receptor; Type 2 InsP3 receptor
Gene Symbols: Itpr2
Molecular weight: 307,475 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene