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IP3R2
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA. Belongs to the InsP3 receptor family. Isoform Short is found in skeletal muscle and heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of mouse Ortholog: 6 G3|6 77.7 cM |
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Cellular Component:
axon; cell cortex; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; nucleoplasm; plasma membrane; receptor complex; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; secretory granule membrane
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Molecular Function:
calcium channel activity; calcium ion binding; calcium-release channel activity; inositol 1,4,5 trisphosphate binding; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; monoatomic ion channel activity; phosphatidylinositol binding; protein binding; scaffold protein binding; transmembrane transporter binding
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Biological Process:
calcium ion transmembrane transport; calcium ion transport; calcium-mediated signaling; cellular response to cAMP; cellular response to ethanol; inositol phosphate-mediated signaling; monoatomic ion transport; release of sequestered calcium ion into cytosol; response to hypoxia; transmembrane transport
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Reference #:
Q9Z329
(UniProtKB)
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Alt. Names/Synonyms: AI649341; inositol 1,4,5-triphosphate receptor 2; inositol 1,4,5-triphosphate receptor 5; Inositol 1,4,5-trisphosphate receptor type 2; Inositol 1,4,5-trisphosphate type V receptor; inositol trisphosphate receptor type 2; InsP3R-2; InsP3R-5; InsP3R2; IP3 receptor; IP3 receptor isoform 2; IP3R 2; Ip3r2; Itpr2; Itpr5; OTTMUSP00000031144; OTTMUSP00000031145; Type 2 inositol 1,4,5-trisphosphate receptor; Type 2 InsP3 receptor
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Gene Symbols: Itpr2
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Molecular weight:
307,475 Da
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Basal Isoelectric point:
6.02
Predict pI for various phosphorylation states
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