ING4 Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11. Belongs to the ING family. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Tumor suppressor
Chromosomal Location of mouse Ortholog: 6 F2|6 59.17 cM
Cellular Component:  cytosol; histone acetyltransferase complex; intermediate filament cytoskeleton; nucleoplasm; nucleus
Molecular Function:  histone H3K14 acetyltransferase activity; histone H4K12 acetyltransferase activity; histone H4K5 acetyltransferase activity; histone H4K8 acetyltransferase activity; metal ion binding; methylated histone binding; protein binding; transcription coactivator activity
Biological Process:  apoptotic process; cell cycle; chromatin organization; DNA replication-dependent chromatin disassembly; histone H4-K12 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone modification; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; negative regulation of growth; positive regulation of apoptotic process; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; protein acetylation; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cell growth; regulation of DNA biosynthetic process; regulation of DNA-templated transcription
Reference #:  Q8C0D7 (UniProtKB)
Alt. Names/Synonyms: D6Wsu147; D6Wsu147e; D6Xrf9; D6Xrf92; ING1-like protein; Ing4; inhibitor of growth family, member 4; Inhibitor of growth protein 4; OTTMUSP00000029000; p29I; p29ING4
Gene Symbols: Ing4
Molecular weight: 28,528 Da
Basal Isoelectric point: 7.53  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene