ING4 similar to ING1, a tumor suppressor protein that can interact with p53, inhibit cell growth, and induce apoptosis. Contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind p53 and p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Tumor suppressor
Chromosomal Location of Human Ortholog: 6 F2|6 59.17 cM
Cellular Component:  cytosol; histone acetyltransferase complex; intermediate filament cytoskeleton; nucleus
Molecular Function:  metal ion binding; methylated histone binding; protein binding; transcription coactivator activity
Biological Process:  apoptotic process; cell cycle; cell cycle arrest; chromatin organization; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA replication; histone acetylation; histone H3 acetylation; histone H4-K12 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; negative regulation of cell proliferation; negative regulation of growth; negative regulation of transcription, DNA-templated; positive regulation of apoptotic process; protein acetylation
Reference #:  Q8C0D7 (UniProtKB)
Alt. Names/Synonyms: D6Wsu147e; D6Xrf92; ING1-like protein; Ing4; inhibitor of growth family, member 4; Inhibitor of growth protein 4; OTTMUSP00000029000; p29ING4
Gene Symbols: Ing4
Molecular weight: 28,528 Da
Basal Isoelectric point: 7.53  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene