IL2RA Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 2 A1|2 8.91 cM
Cellular Component:  cell surface; external side of plasma membrane; integral component of membrane; membrane
Molecular Function:  interleukin-2 binding; interleukin-2 receptor activity; protein binding
Biological Process:  activation-induced cell death of T cells; immune system process; inflammatory response to antigenic stimulus; negative regulation of defense response to virus; negative regulation of immune response; negative regulation of inflammatory response; negative regulation of lymphocyte proliferation; negative regulation of T cell proliferation; Notch signaling pathway; positive regulation of activated T cell proliferation; positive regulation of T cell differentiation; positive regulation of T cell proliferation; regulation of T cell homeostatic proliferation; regulation of T cell tolerance induction; T cell homeostasis
Reference #:  P01590 (UniProtKB)
Alt. Names/Synonyms: CD25; IL-2 receptor subunit alpha; IL-2-RA; IL-2R alpha chain; IL-2R subunit alpha; IL2-RA; Il2r; Il2ra; interleukin 2 receptor, alpha chain; Interleukin-2 receptor subunit alpha; Ly-43; MGC130561; OTTMUSP00000012002; p55; p55 chain
Gene Symbols: Il2ra
Molecular weight: 30,723 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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IL2RA

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene