HIVEP2 This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. Expressed in brain and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding
Chromosomal Location of Human Ortholog: 10|10 A2
Cellular Component:  nucleoplasm; nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; metal ion binding; nucleic acid binding; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  positive regulation of transcription by RNA polymerase II; signal transduction; transcription, DNA-templated
Reference #:  Q3UHF7 (UniProtKB)
Alt. Names/Synonyms: Hivep2; human immunodeficiency virus type I enhancer binding protein 2; Human immunodeficiency virus type I enhancer-binding protein 2 homolog; MIBP-1; Mibp1; Myc intron-binding protein 1; Schnurri-2; Shn-2; Transcription factor HIVEP2; ZEP2
Gene Symbols: Hivep2
Molecular weight: 266,705 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
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HIVEP2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene