FIP1L1 Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. Belongs to the FIP1 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA-binding
Chromosomal Location of mouse Ortholog: 5|5 C3.3
Cellular Component:  mRNA cleavage and polyadenylation specificity factor complex; nucleoplasm; nucleus
Molecular Function:  enzyme regulator activity; protein binding; RNA binding
Biological Process:  mRNA processing; regulation of mRNA 3'-end processing
Reference #:  Q9D824 (UniProtKB)
Alt. Names/Synonyms: 1300019H17Rik; FIP1; FIP1 like 1 (S. cerevisiae); FIP1-like 1 protein; Fip1l1; Pre-mRNA 3'-end-processing factor FIP1; Rje
Gene Symbols: Fip1l1
Molecular weight: 64,959 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
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FIP1L1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene