FGA Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. Detected in blood plasma (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of mouse Ortholog: 3 E3|3 36.96 cM

Cellular Component: blood microparticle; cell cortex; cell surface; endoplasmic reticulum; external side of plasma membrane; extracellular region; extracellular space; fibrinogen complex; platelet alpha granule; synapse

Molecular Function: cell adhesion molecule binding; extracellular matrix structural constituent; metal ion binding; signaling receptor binding; structural molecule activity

Biological Process: adaptive immune response; blood coagulation; blood coagulation, common pathway; blood coagulation, fibrin clot formation; cell-matrix adhesion; fibrinolysis; hemostasis; immune system process; induction of bacterial agglutination; innate immune response; negative regulation of endothelial cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; plasminogen activation; platelet activation; platelet aggregation; positive regulation of ERK1 and ERK2 cascade; positive regulation of exocytosis; positive regulation of heterotypic cell-cell adhesion; positive regulation of peptide hormone secretion; positive regulation of protein secretion; positive regulation of smooth muscle cell migration; positive regulation of vasoconstriction; protein polymerization; protein-containing complex assembly; response to calcium ion

Reference #: E9PV24 (UniProtKB)

Alt. Names/Synonyms: ENSMUSG00000059807; Fga; Fib; FIBA; Fibrinogen alpha chain; fibrinogen, A alpha polypeptide; Fibrinogen, alpha polypeptide; Fibrinopeptide A

Gene Symbols: Fga

Molecular weight: 87,429 Da

Basal Isoelectric point: 5.78 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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FGA

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