EVL Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. Belongs to the Ena/VASP family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12|12 F1
Cellular Component:  cell projection; cytoplasm; cytoskeleton; focal adhesion; lamellipodium; phagocytic vesicle
Molecular Function:  actin binding; profilin binding; protein binding; SH3 domain binding
Biological Process:  actin filament-based movement; actin nucleation; actin polymerization or depolymerization; axon guidance; barbed-end actin filament capping; cellular response to interferon-gamma; negative regulation of epithelial cell migration; negative regulation of ruffle assembly; platelet activation; positive regulation of actin filament polymerization; positive regulation of stress fiber assembly; protein homotetramerization
Reference #:  P70429 (UniProtKB)
Alt. Names/Synonyms: AI528774; b2b2600C; b2b2600Clo; Ena-vasodilator stimulated phosphoprotein; Ena/vasodilator-stimulated phosphoprotein-like; Ena/VASP-like protein; Evl
Gene Symbols: Evl
Molecular weight: 44,337 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene