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EVL
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. Belongs to the Ena/VASP family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 12|12 F1 |
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Cellular Component:
cell projection; cytoplasm; cytoskeleton; focal adhesion; lamellipodium; phagocytic vesicle
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Molecular Function:
actin binding; profilin binding; protein binding; SH3 domain binding
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Biological Process:
actin filament-based movement; actin nucleation; actin polymerization or depolymerization; axon guidance; barbed-end actin filament capping; cellular response to type II interferon; negative regulation of epithelial cell migration; negative regulation of ruffle assembly; platelet activation; positive regulation of actin filament polymerization; positive regulation of stress fiber assembly; protein homotetramerization
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Reference #:
P70429
(UniProtKB)
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Alt. Names/Synonyms: AI528774; b2b2600C; b2b2600Clo; Ena-vasodilator stimulated phosphoprotein; Ena/vasodilator-stimulated phosphoprotein-like; Ena/VASP-like protein; Evl
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Gene Symbols: Evl
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Molecular weight:
44,337 Da
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Basal Isoelectric point:
8.92
Predict pI for various phosphorylation states
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